منابع مشابه
Uptake of novel oral anticoagulants in Australia.
linical trials have shown that novel oral anticoagulants C (NOACs) are as efficacious as warfarin in reducing the riskof stroke in patients with atrial fibrillation. However, concerns regarding efficacy and safety in real-world populations remain, particularly in patients aged 75 years and older and those with comorbid conditions. Three NOACs — dabigatran, rivaroxaban and apixaban— were listed ...
متن کاملThe novel oral anticoagulants: A new frontier
“A ctionable” oncogenic drivers – genetic mutations that are critical to the development and maintenance of a cancer and that are susceptible to targeted therapy – were identified in 64% of tumor samples from 733 patients with lung adenocarcinoma in a proof-ofconcept study aimed at determining the frequency of such mutations that was reported in JAMA. The researchers used multiplexed genetic te...
متن کاملNovel oral anticoagulants for acute coronary syndrome.
Acute coronary syndrome (ACS) is a cardiovascular condition with a multifactorial pathophysiology that includes atherosclerotic plaques, platelet activation and thrombin production, among others. Thrombin production and the prothrombotic state of ACS patients have provided a role for anticoagulants to treat patients during the acute event and has led to subsequent research for the post-acute st...
متن کاملNovel antidotes for target specific oral anticoagulants
Target specific oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) are changing the landscape of anticoagulation. The major drawback is the absence of an effective antidote for severe bleedings and/or prior to procedures. Currently there are a few promising antidotes undergoing clinical trials. This review summarized the latest development in idarucizumab, andexanet alpha and...
متن کاملAn Overview of Novel Anticoagulants
Arterial and venous thromboembolism is one of the most common causes of death worldwide. For almost seventy years, heparin, low molecular weight heparin, and vitamin K antagonists have been widely used in the prevention and treatment of thromboembolic disorders. However, many of the limitations of these traditional anticoagulants have led to the search for and attempts to introduce better drug ...
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ژورنال
عنوان ژورنال: International Journal of Clinical Practice
سال: 2009
ISSN: 1368-5031,1742-1241
DOI: 10.1111/j.1742-1241.2009.02011.x